Cannabis Drug Interactions

Acetaminophen (Paracetamol)

Brands: Tylenol, Panadol, Mapap

Understand the low-risk interaction between cannabis and acetaminophen (Tylenol), including shared CYP450 metabolism, liver considerations, and clinical recommendations for pain management.

lisinopril

Brands: Zestril, Prinivil

Learn about the interaction between cannabis and lisinopril (Zestril). Understand the low risk of additive hypotension and when to be cautious with blood pressure effects.

warfarin

Brands: Coumadin, Jantoven

Critical information about the interaction between cannabis and warfarin (Coumadin). Understand how CBD inhibits CYP2C9, elevates INR, and increases bleeding risk.

Brands: Keppra, Keppra XR, Spritam

Learn about the low-risk interaction between cannabis and levetiracetam (Keppra), including how CBD may alter anticonvulsant levels, shared seizure management implications, and monitoring recommendations.

Brands: Tegretol, Tegretol XR, Carbatrol

Understand the high-risk interaction between cannabis and carbamazepine (Tegretol), including significant CYP3A4 enzyme induction that reduces CBD levels, seizure control implications, and critical monitoring requirements.

gabapentin

Brands: Neurontin, Gralise, Horizant

Understand the interaction between cannabis and gabapentin (Neurontin). Learn about additive sedation, dizziness risks, and safety recommendations for combining these substances.

Brands: Lyrica, Lyrica CR

Explore the moderate-risk interaction between cannabis and pregabalin (Lyrica), including additive sedation and dizziness, CNS depression concerns, and recommendations for patients managing pain or seizures.

Brands: Benadryl, ZzzQuil, Sominex

Understand the moderate-risk interaction between cannabis and diphenhydramine (Benadryl). Learn about additive sedation, anticholinergic effects, and safety considerations.

Brands: Cozaar

Understand the moderate-risk interaction between cannabis and losartan. Learn how CBD inhibition of CYP2C9 can affect losartan metabolism and blood pressure control.

alprazolam

Brands: Xanax, Xanax XR

Critical information about cannabis interactions with alprazolam (Xanax). Understand the high risk of enhanced CNS depression, CYP3A4 inhibition by CBD, and safety guidelines.

clonazepam

Brands: Klonopin

Important safety information about cannabis interactions with clonazepam (Klonopin). Understand the high risk of additive sedation, CNS depression, and safety precautions.

lorazepam

Brands: Ativan

Learn about cannabis interactions with lorazepam (Ativan). Understand why this benzodiazepine has less CYP450 interaction but still carries additive sedation risks.

Brands: Valium, Diastat, Valtoco

Understand the high-risk interaction between cannabis and diazepam (Valium). Learn about the dangerous combination of CYP3A4/CYP2C19 inhibition with additive sedation and respiratory depression risks.

metoprolol

Brands: Lopressor, Toprol-XL

Understand the interaction between cannabis and metoprolol (Lopressor). Learn about CYP2D6 inhibition by CBD, additive hypotension, and cardiovascular safety considerations.

Brands: Glucophage, Glumetza, Fortamet

Learn about the interaction between cannabis and metformin, including effects on blood sugar regulation, CYP450 metabolism, and safety recommendations for diabetic patients.

Brands: Eliquis

Learn about the high-risk interaction between cannabis and apixaban (Eliquis). Understand how CYP3A4 interaction can increase bleeding risk with this blood thinner.

Brands: Norvasc, Katerzia, Amvaz

Understand the moderate-risk interaction between cannabis and amlodipine (Norvasc), including CYP3A4 metabolic competition, additive blood pressure lowering, and cardiovascular monitoring recommendations.

Amphetamine/Dextroamphetamine

Brands: Adderall, Adderall XR, Mydayis

Explore the moderate-risk interaction between cannabis and Adderall (amphetamine), including opposing cardiovascular effects, CYP2D6 metabolism considerations, and clinical recommendations.

Brands: Ritalin, Concerta, Focalin

Review the moderate-risk interaction between cannabis and methylphenidate (Ritalin/Concerta), including heart rate and blood pressure concerns, metabolic pathways, and clinical guidance for ADHD patients.

Brands: Deltasone, Rayos, Prednisone Intensol

Learn about the low-risk interaction between cannabis and prednisone, including shared immunomodulatory effects, CYP3A4 metabolism, and practical guidance for patients on corticosteroid therapy.

Combined Oral Contraceptive (Ethinyl Estradiol / Levonorgestrel)

Brands: Yaz, Ortho Tri-Cyclen, Lo Loestrin

Learn about the low-risk interaction between cannabis and birth control pills. Understand the minor CYP3A4 pathway interaction and what it means for contraceptive effectiveness.

Insulin (various formulations)

Brands: Humalog, Novolog, Lantus

Understand the moderate-risk interaction between cannabis and insulin, including unpredictable blood sugar effects, hypoglycemia risks, and monitoring strategies for diabetic patients.

Brands: Flexeril, Amrix, Fexmid

Learn about the moderate-risk interaction between cannabis and cyclobenzaprine (Flexeril). Understand the risks of additive CNS depression and CYP1A2 metabolic interaction.

bupropion

Brands: Wellbutrin, Zyban, Aplenzin

Learn about cannabis interactions with bupropion (Wellbutrin). Understand the CYP2B6 metabolic pathway, seizure threshold concerns, and safety recommendations.

Brands: Advil, Motrin, Nuprin

Review the low-risk interaction between cannabis and ibuprofen (Advil/Motrin), including shared anti-inflammatory mechanisms, additive GI effects, and CYP2C9 metabolism considerations.

hydrocodone

Brands: Vicodin, Norco, Lortab

Critical information about cannabis interactions with hydrocodone (Vicodin). Understand the high risk of enhanced respiratory depression, CYP interactions, and safety measures.

oxycodone

Brands: OxyContin, Percocet, Roxicodone

Critical safety information about cannabis interactions with oxycodone (OxyContin). Learn about CYP3A4 inhibition, enhanced respiratory depression, and life-saving precautions.

tramadol

Brands: Ultram, ConZip

Critical safety information about cannabis interactions with tramadol (Ultram). Understand seizure threshold risks, serotonin syndrome danger, and CYP2D6 interactions.

Brands: Viagra, Revatio

Understand the moderate-risk interaction between cannabis and sildenafil (Viagra). Learn about additive hypotension, heart rate effects, and safety precautions.

Brands: Prilosec, Prilosec OTC, Zegerid

Learn about the low-risk interaction between cannabis and omeprazole (Prilosec), including CYP2C19 metabolic competition, potential effects on cannabis metabolism, and practical considerations for GI health.

Brands: Ambien, Ambien CR, Edluar

Understand the high-risk interaction between cannabis and zolpidem (Ambien), including dangerous additive CNS depression, CYP3A4 metabolism competition, and critical safety information.

sertraline

Brands: Zoloft

Learn about the interaction between cannabis (CBD and THC) and sertraline (Zoloft). Understand CYP2C19 and CYP2D6 inhibition risks, symptoms, and safety recommendations.

fluoxetine

Brands: Prozac, Sarafem

Understand the interaction between cannabis and fluoxetine (Prozac). Learn how CBD inhibits CYP2D6 metabolism, affecting fluoxetine levels and potential side effects.

escitalopram

Brands: Lexapro

Explore the interaction between cannabis and escitalopram (Lexapro). Understand CYP3A4 and CYP2C19 metabolic pathways and what to watch for when combining these substances.

venlafaxine

Brands: Effexor, Effexor XR

Discover how cannabis interacts with venlafaxine (Effexor). Learn about CYP2D6 pathway inhibition by CBD, serotonin syndrome risk, and important safety precautions.

Brands: Natrol Melatonin, ZzzQuil Pure Zzzs, Nature Made Melatonin

Learn about the minimal-risk interaction between cannabis and melatonin supplements, including additive drowsiness, potential complementary sleep mechanisms, and practical usage tips.

Brands: Cymbalta, Irenka

Learn about the moderate-risk interaction between cannabis and duloxetine (Cymbalta). Understand the CYP1A2 and CYP2D6 metabolic interactions and effects on pain and mood management.

Brands: Celexa

Learn about the moderate-risk interaction between cannabis and citalopram (Celexa). Understand the CYP2C19 and CYP3A4 pathway interactions and effects on mental health treatment.

Brands: Paxil, Pexeva, Brisdelle

Understand the moderate-risk interaction between cannabis and paroxetine (Paxil). Learn how paroxetine's strong CYP2D6 inhibition affects cannabinoid metabolism and what to watch for.

Brands: Lipitor

Learn about the moderate-risk interaction between cannabis (especially CBD) and atorvastatin (Lipitor). Understand how CYP3A4 inhibition by CBD can increase statin levels and side effect risk.

Explore the minimal-risk interaction between cannabis and caffeine. Understand how these substances have opposing effects on alertness and how they interact in the body.

Understand the low-risk interaction between cannabis and nicotine. Learn how both substances affect dopamine pathways and contribute to combined cardiovascular stress.

Ethanol

Learn about the high-risk interaction between cannabis and alcohol. Understand how combining these substances causes additive impairment and increases THC blood levels.

Brands: Synthroid, Levoxyl, Tirosint

Review the low-risk interaction between cannabis and levothyroxine (Synthroid), including potential absorption interference, thyroid function monitoring, and practical administration tips.