Nerolidol

Nerolidol, also known as peruviol or penetrol, is a sesquiterpene alcohol found in many aromatic plants including cannabis, jasmine, tea tree, and neroli (the essential oil of bitter orange blossoms, from which it derives its name). This terpene exists in two isomeric forms — cis-nerolidol and trans-nerolidol — both contributing a subtle, woody, fresh aroma with floral undertones that add depth and complexity to cannabis strain profiles. One of nerolidol's most significant and unique properties is its ability to enhance the penetration of other compounds through biological membranes, including human skin. This transdermal enhancement capability has made nerolidol the subject of extensive pharmaceutical research, as it could potentially improve the delivery of medications through topical and transdermal applications. In cannabis topicals, the presence of nerolidol may increase the absorption of cannabinoids like THC and CBD through the skin, potentially enhancing the effectiveness of cannabis-infused creams and balms. Nerolidol also demonstrates potent anti-parasitic activity — research has shown effectiveness against the malaria parasite Plasmodium falciparum, the leishmaniasis parasite, and various fungal pathogens. The terpene's sedative properties have been confirmed in animal studies, where inhaled nerolidol reduced locomotor activity and increased sleep time. In cannabis, nerolidol is typically a minor terpene, but its presence can noticeably shift the character of a strain's effects toward deeper relaxation and sedation, particularly when combined with myrcene and linalool.